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Title: Liver progenitor cells and Kupffer cells - good friends - by George Yeoh
Author: asscr2017
Votes: 9

Views: 373
Description: Liver progenitor cells and Kupffer cells - good friends
Submitted by: George Yeoh (Harry Perkins Institute of Medical Research)

The image is a section of liver from a mouse model of fatty liver disease that involves inflammation. It depicts clusters of liver progenitor cells (LPCs) characterised by blue ovoid nuclei (DAPI) and staining for CK19 (green cytoplasm). These LPCs appear among hepatocytes that contain large blue circular nuclei (DAPI). More importantly, many LPCs and Kupffer cells that are F4/80 positive (red cytoplasm) are juxtaposed. This prompted our focus on the Kupffer cell as the cellular initiator of liver regeneration that is sourced from LPCs.

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