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Title: Meso-Endothelial Bipotent Progenitors - by Abbas Shafiee
Author: asscr2017
Votes: 986

Views: 3939
Description: Meso-Endothelial Bipotent Progenitors
Submitted by: Abbas Shafiee (IHBI, Queensland University of Technology)

The existence of bipotential precursors for both mesenchymal and endothelial stem/progenitor cells in human postnatal life is debated. We found that such progenitors are present within the human term placenta. From a heterogeneous placental single-cell suspension, a directly flow-sorted CD45−CD34+CD144+CD31Lo population uniquely differentiated into both endothelial and mesenchymal colonies in limiting dilution culture assays. Of interest, these bipotent cells were in vessel walls but not in contact with the circulation. RNA sequencing and functional analysis demonstrated that Notch signalling was a key driver for endothelial and bipotential progenitor function. In contrast, the formation of mesenchymal cells from the bipotential population was not affected by TGFβ receptor inhibition, a classical pathway for endothelial-mesenchymal transition. This study reveals a bipotent progenitor phenotype in the human placenta at the cellular and molecular levels, giving rise to endothelial and mesenchymal cells ex vivo. Image shows placenta tissue which is stained for DAPI (Blue), CD31 (Green) and SNAI (Red)).


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