Select “Most Voted” using the drop down menu below to sort by top voted images.

Congratulations to the winners and thank you to ThermoFisher for sponsoring the prizes!

Top Voted Images: VINOD SUNDARAMOORTHY (1st)?, ABBAS SHAFIEE (2nd) ?, GAUTAM WALI (3rd) ?MIKE DORAN (4th ?) & AIDA SHAKOURI (5th ?).

Back to image gallery.

Previous photoNext photo
Contest is finished!
Title: Generating neurons to model Parkinson’s Disease in a dish - by Joan Ho
Author: asscr2017
Votes: 53

Views: 404
Description: Generating neurons to model Parkinson’s Disease in a dish
Submitted by: Joan Ho (Monash University)

This image shows an emerging cluster of human embryonic stem cell-derived neurons in a culture dish successfully differentiating toward a midbrain dopaminergic (mDA) neuron phenotype. We are able to visualise this differentiation in real-time by generating a fluorescent reporter cell line to track the expression of a mDA progenitor marker LMX1A in the culture (LMX1AeGFP/wt, green). Immunofluorescent staining of beta-III-tubulin (white) confirms neuronal identity in the culture, with cell nuclei shown in blue. mDA neurons ultimately degenerate in Parkinson's Disease - hence, the generation of a reporter line to enrich this population in culture is key in modelling Parkinson's Disease in a dish.

EMAIL
Twitter
Facebook
Google+
Pinterest
LinkedIn
SHARE

For contest rules and prizes, click here.