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Title: Organoids in the slammer? - by Kathryn Futrega
Author: asscr2017
Votes: 55

Views: 1367
Description: Organoids in the slammer?
Submitted by: Kathryn Futrega (Translational Research Institute, Science and Engineering Faculty, Queensland University of Technology)

That’s right, they’re staying put! When grown in microwell arrays, cells self-assemble into spheroidal structures, often referred to as “spheroids”, or “organoids” when they resemble tiny organ-like structures. When mesenchymal stromal cells are differentiated down the chondrogenic lineage using growth factors like TGF-beta, they become very sticky spheroids. This makes it hard to maintain them in their discrete microwells, especially over long culture periods and many turbulent media exchanges. To ensure these spheroids stay put in their individual microwells, we have developed the "Microwell-mesh". This tissue culture device consists of a microwell array, covered with a porous nylon mesh. Single cells are small enough to enter the microwells, but once amalgamated, the large spheroids can’t get back out. The Microwell-mesh maintains spheroids in discrete microwells, like a “tiny prison”. (Original publication in Biomaterials, 2015, 62:1-12).


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