Stem Cell breakthrough
Stem cell researchers from Monash University and the University of Melbourne have shown that Snail family member, Snai1, is instrumental in regulating the fate of intestinal stem cells. The research, led by Monash University’s Associate Professor Helen Abud and Associate Professor Gary Hime from The University of Melbourne, has been published in EMBO J.
Using a conditional knockout mouse the researchers demonstrated that Snai1 is required for maintenance of crypt base columnar stem cells in the intestine and also for epithelial regeneration. These findings have important implications for the treatment of bowel diseases and colorectal cancer.
Horvay et al. (2015) Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium. EMBO J (conditions apply)
Media coverage:Ancient gene a possible key to curing bowel disease The Age 15 March 2015
Cancer-linked protein helps control fate of Intestinal stem cells.
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